Gene regulatory effects have been difficult to detect at many non-coding loci associated with brain-related traits, likely because some genetic variants have distinct functions in specific contexts. To explore context-dependent gene regulation, we measured chromatin accessibility and gene expression after activation of the canonical Wnt pathway in primary human neural progenitors. We identified many context-dependent genetic effects, some of which help explain the mechanisms underlying brain-related traits. This work was published in Nature Neuroscience.