Oleh Krupa led a project to develop a tool used for analyzing tissue cleared images. He imaged WT and Top1 cKO mice, getting beautiful cellular resolution images of the entire brain. Using the tool he developed, he was able to accurately quantify all nuclei in the cortex, accurately count individual cell types, and identify differences in cell type proportions and density between the genotype groups. This is a tool that we hope will be widely useful to the research community for studying genetically mediated differences in brain structure!